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Protein misfolding: from structural biology to molecular mechanisms of disease
SIMBE 2021
The Symposium
The first edition of the Symposium on Structural Biology 2021 (SimBE 2021) will be focused on the molecular mechanisms of human diseases associated with protein misfolding, including cancer and neurodegenerative diseases.
With the increased longevity and aging of the human population, the prevalence of age-related disorders keeps growing. Therefore, it is crucial to unravel the molecular processes that lead to the development of these diseases as this will enable the discovery of novel therapeutic targets.
The event takes place ONLINE, on the Even3 platform.
Dates
NOV
09
NOV
10
NOV
11
BEGINS IN
Days
Hours
Minutes
Seconds
Program
NOV
09
INICIO
12:00hs
GMT-3
Structural biology of protein misfolding and aggregation
13:00hs
Guilherme Augusto Piedade de Oliveira
Federal University of Rio de Janeiro
Cryo-EM to visualize pathological protein filaments at near atomic resolution
Cryo-EM to visualize pathological protein filaments at near atomic resolution
13:30hs
Byron Caughey
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, EUA
High-resolution structures and strain comparison of infectious mammalian prions
High-resolution structures and strain comparison of infectious mammalian prions
14:00hs
Discussion session
NOV
10
INICIO
12:00hs
GMT-3
Protein aggregation and phase separation
12:00hs
Samrat Mukhopadhyay
Indian Institute of Science Education and Research, Mohali
The Role of Intrinsic Disorder in Liquid-Liquid Phase Separation
The Role of Intrinsic Disorder in Liquid-Liquid Phase Separation
12:30hs
Jerson Lima da Silva
Federal University of Rio de Janeiro
Phase Transition and Aggregation of Mutant p53 as Therapeutic Targets in Cancer
Phase Transition and Aggregation of Mutant p53 as Therapeutic Targets in Cancer
13:00hs
James Shorter
University of Pennsylvania
Countering deleterious phase transitions in ALS/FTD
Countering deleterious phase transitions in ALS/FTD
13:30hs
Yraima Cordeiro
Federal University of Rio de Janeiro
Understanding the role of prion protein binding partners in its phase transitions
Understanding the role of prion protein binding partners in its phase transitions
14:00hs
Discussion session
NOV
11
INICIO
09:00hs
GMT-3
From mechanisms to targets in protein misfolding diseases
09:00hs
Tiago Fleming Outeiro
University Medical Center Göttingen
Hitting the sweet spot: glycation as a mechanism and target in synucleinopathies
Hitting the sweet spot: glycation as a mechanism and target in synucleinopathies
09:30hs
Debora Foguel
Universidade Federal do Rio de Janeiro
The role of inflammation in amyloidosis
The role of inflammation in amyloidosis
10:00hs
Aaron Gitler
Stanford University
Expanding mechanisms and therapeutic targets for neurodegenerative disease
Expanding mechanisms and therapeutic targets for neurodegenerative disease
11:00hs
Discussion session
Registrations
Registration for SimBE 2021 will run until November 2nd, on the Even3 platform*.
Participation at the event is free of charge, but registration is mandatory.
* When accessing the platform for the first time, you will be required to create an account. After signing up, enter your username and password to complete your registration.
Organizing Committee
Tuane C. R. G. Vieira
Federal University of Rio de Janeiro
Jerson Lima Silva
Federal University of Rio de Janeiro
Tiago O. Fleming Outeiro
University Medical Center Göttingen
Organizers
Sponsor
Sponsor
