Protein misfolding: from structural biology to molecular mechanisms of disease

SIMBE 2021

The Symposium

The first edition of the Symposium on Structural Biology 2021 (SimBE 2021) will be focused on the molecular mechanisms of human diseases associated with protein misfolding, including cancer and neurodegenerative diseases.

With the increased longevity and aging of the human population, the prevalence of age-related disorders keeps growing. Therefore, it is crucial to unravel the molecular processes that lead to the development of these diseases as this will enable the discovery of novel therapeutic targets.

The event takes place ONLINE, on the Even3 platform.

Dates

NOV

09

NOV

10

NOV

11

BEGINS IN

Days
Hours
Minutes
Seconds

Program

NOV

09

INICIO

12:00hs
GMT-3

Structural biology of protein misfolding and aggregation

12:00hs

Tuane Cristine R. G. Vieira

Federal University of Rio de Janeiro

Opening session

12:30hs

Enrico Gratton

University of California, Irvine

13:00hs

Guilherme Augusto Piedade de Oliveira

Federal University of Rio de Janeiro

Cryo-EM to visualize pathological protein filaments at near atomic resolution

13:30hs

Byron Caughey

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, EUA

High-resolution structures and strain comparison of infectious mammalian prions

14:00hs

Discussion session

NOV

10

INICIO

12:00hs
GMT-3

Protein aggregation and phase separation

12:00hs

Samrat Mukhopadhyay

Indian Institute of Science Education and Research, Mohali

The Role of Intrinsic Disorder in Liquid-Liquid Phase Separation

12:30hs

Jerson Lima da Silva

Federal University of Rio de Janeiro

Phase Transition and Aggregation of Mutant p53 as Therapeutic Targets in Cancer

13:00hs

James Shorter

University of Pennsylvania

Countering deleterious phase transitions in ALS/FTD

13:30hs

Yraima Cordeiro

Federal University of Rio de Janeiro

Understanding the role of prion protein binding partners in its phase transitions

14:00hs

Discussion session

NOV

11

INICIO

09:00hs
GMT-3

From mechanisms to targets in protein misfolding diseases

09:00hs

Tiago Fleming Outeiro

University Medical Center Göttingen

Hitting the sweet spot: glycation as a mechanism and target in synucleinopathies

09:30hs

Debora Foguel

Universidade Federal do Rio de Janeiro

The role of inflammation in amyloidosis

10:00hs

Aaron Gitler

Stanford University

Expanding mechanisms and therapeutic targets for neurodegenerative disease

10:30hs

Elis Eleuthério

Federal University of Rio de Janeiro

Inside ALS: the role of Sod1

11:00hs

Discussion session

Registrations

Registration for SimBE 2021 will run until November 2nd, on the Even3 platform*.

Participation at the event is free of charge, but registration is mandatory.

* When accessing the platform for the first time, you will be required to create an account. After signing up, enter your username and password to complete your registration.

Organizing Committee

Tuane C. R. G. Vieira

Federal University of Rio de Janeiro

Jerson Lima Silva

Federal University of Rio de Janeiro

Tiago O. Fleming Outeiro

University Medical Center Göttingen

Organizers

Sponsor

Sponsor

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